Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper
نویسندگان
چکیده
منابع مشابه
Achieving photo-control of protein conformation and activity: producing a photo-controlled leucine zipper.
We have recently developed a technique that has great potential in producing proteins with photo-control of conformation and consequently activity (J. R. Kumita, O. S. Smart and G. A. Woolley, Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 3803-3808). The method is based on incorporating two cysteine residues into the sequence of a polypeptide. An azobenzene derivative is subsequently used to produ...
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The leucine zipper is the dimerization domain of the B-ZIP (basic-region leucine zipper) class of eukaryotic transcription factors (Vinson et al., 1989). The name arose because leucines occur every seven amino acids in this dimerization domain.These leucines are critical for the dimerization and DNA binding of B-ZIP proteins. The leucine zipper is a left-handed parallel dimeric coiled-coil, a s...
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ژورنال
عنوان ژورنال: Faraday Discussions
سال: 2002
ISSN: 1359-6640,1364-5498
DOI: 10.1039/b200897a